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The combination adds $200400/month in medication cost and requires resistance training 34 times weekly plus protein intake at 1.62.0 g/kg body weight daily to see meaningful lean mass preservation

In Eli Lillys Phase 2 trial published in NEJM in 2023, participants on the highest dose (12 mg weekly) lost an average of 24.2% of their body weight over 48 weeks

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doi: 10.3390/nu11010105 26 GalleggianteV.De SantisS.LisoM.VernaG.SommellaE.MastronardiM.et al

Compounded tirzepatide is prepared by a state-licensed compounding pharmacy under physician supervision

Clinics like MEDVi require monthly follow-ups and include video consultations