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Preclinical and limited human studies indicate DSIP may modulate the hypothalamicpituitaryadrenal (HPA) axis and support healthy cortisol rhythms, making it of interest in stress-related sleep disruption

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J Clin Oncol 30:34083416

Rat beta 3 subunits expressed in human embryonic kidney 293 cells form high affinity [35S]t-butylbicyclophosphorothionate binding sites modulated by several allosteric ligands of gamma-aminobutyric acid type A receptors