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postmarketing reports) Hypersensitivity or anaphylactoid reactions to the oil vehicle (rare) Cardiovascular events in high-risk individuals Sodium and water retention with edema Important safety note: Do not take this medication if you use nitrates (for chest pain) or certain blood-pressure medications, the combination can cause a dangerous drop in blood pressure

For a detailed walkthrough, see our [switching from semaglutide to tirzepatide guide](/guides/switching-from-semaglutide-to-tirzepatide-complete-guide)

Injection site reactions deserve special attention in autoimmune patients

A healthcare professional will typically conduct blood tests to diagnose a B12 deficiency before recommending injections

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