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Bernal-Orozco MF, Vizmanos B, Hunot C, Flores-Castro M, Leal-Mora D, Cells A, Fernandez-Ballart JD

Picomolar A concentration unit equal to 10 molar

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Although the C-terminal SAM-binding site is located away from the catalytic center, it was revealed that SAM binding induces a structural rearrangement of the catalytic core that relieves autoinhibition and stabilizes an activated conformation (McCorvie et al., 2014