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Lamictal is not a medicine to change casually because dose timing, interactions, and release type can matter

The apparent physiological opposition between GLP-1 and GCG does not preclude pharmacological synergy, since GLP-1/GCG dual agonists are engineered to achieve balanced receptor activation rather than simple co-administration of two counter-regulatory hormones (61,64)

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1998 Sep ;91(9):873-4

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Start with the lowest recommended dose and increase gradually, and always maintain high water intake