Perioperative neurocognitive dysfunction: thinking from the gut
Cys115 and 174 in GSTM2 were the only sites with detectable NAPQI peptides from both protease treatments
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Formulation strategies to improve oral peptide delivery
Clinical considerations for delayed dosing include the potential for breakthrough hyperglycemia in patients with diabetes and increased appetite in those using semaglutide for weight management
The gut microbiota plays a pivotal role, producing metabolites and neurotransmitters that influence brain function via the vagus nerve and enteric nervous system, while the hypothalamicpituitaryadrenal (HPA) axis modulates stress responses, impacting both gut and brain functions (Yang et al., 2018