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The authors suggest that saturation of these enzymes is unlikely to occur with normal human dietary patterns, perhaps explaining the relative stability of muscle carnosine over time (42)

In a clinical trial involving 112 patients, administration of the GLP-1 analogue exenatide led to a 21% faster reduction in blood lactate levels within 6 hours compared to placebo (95% CI: 6.0%33%

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Ruiz-Mercado M, Vargas MT, Prez de Soto I, et al

Because thyroid hormone requirements track with body size, so substantial weight loss can leave a previously appropriate replacement level higher than the body now needs