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5 Clinical use of SGLT2i, GLP-1ra, and dual agonists in cardiovascular-renal-hepatic-metabolic syndrome Sodium-glucose cotransporter 2 (SGLT2) inhibitors have redefined management strategies for patients with CKD, heart failure, and type 2 diabetes, all of which are key components of CRHM syndrome

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Some practitioners suggest methylcobalamin for certain conditions, though robust comparative trials are lacking

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