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[DOI] [PMC free article] [PubMed] [Google Scholar] 21.Cesarec V, Becejac T, Misic M, et al

Kidney function tests, such as serum creatinine and blood urea nitrogen (BUN), may be necessary, particularly in individuals with pre-existing kidney issues

Gastrointestinal disturbances with B12 supplements typically relate to excipients such as sorbitol, mannitol, or lactose rather than the vitamin itself

Only then can we resolve the nature of the interaction, its clinical consequences, and who might be susceptible to its effects

When NNMT is overactive, it consumes S-adenosylmethionine (SAM) and reduces levels of nicotinamide adenine dinucleotide (NAD+), a critical coenzyme involved in cellular energy production