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Jun 2019;24(4):309-316
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Canonical GLP-1RAs, such as liraglutide, semaglutide, and tirzepatide (which possesses dual GLP-1/GIP receptor agonist activity), have consistently demonstrated superior metabolic and cardiorenal outcome benefits in large-scale randomized controlled trials (RCTs) ( Regarding weight reduction, pooled results from clinical trials indicate that, compared to placebo, liraglutide at 3.0 mg/d achieves a placebo-subtracted weight loss of approximately 5%
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It plays a key role in the body's stress response system, helping to regulate blood sugar, blood pressure and the immune system
10 These findings are the crux of why researchers are investigating GLP-1 medications for Alzheimers disease, Parkinsons disease, and other conditions marked by progressive cognitive decline
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