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Aib 13 GLP-1, GIP, GCG (glucagon), and GLP-2 share high homology so that it ought to be considered that GCGR and GLP-2R should sidestep the activation of the designed GLP-1/GIP dual agonist

5.4.2 Effects on liver Despite the lack of expression of GIPR (41, 191) and GLP-1R (192, 193) in hepatocytes, both GIP and GLP-1 have indirect effects on hepatic lipid and glucose metabolism (194)

Intracellular cAMP accumulation was normalized to the total cellular protein concentration

PMID: 40609566 | doi:10.1016/S2213-8587(25)00092-0 Sinha B et al

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Glucagon receptor antagonism and lipid metabolism. Diabetes Obes Metab , 2016