The recognition of RET as the major cause of MTC led to the identification of all the major components of the RET receptor system, an understanding of the role of the receptor system in normal developmental biology of the sympathetic nervous system, and the beginnings of an understanding of how mutations of RET cause transformation
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Spielman LJ, Little JP, Klegeris A (2014) Inflammation and insulin/IGF-1 resistance as the possible link between obesity and neurodegeneration
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Its efficacy in asthma and ILDs remains uncertain