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However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional

2026 Feb 12:e256262

People using these medicines can lose more weight than with diet and exercise alone a loss of between 5% and 21% of their body weight can be expected depending on which medicine is taken and how long it is used

That includes: People who are pregnant or planning to become pregnant People with a personal or family history of kidney problems People with a personal or family history of pancreatitis People with a personal or family history of medullary thyroid cancer People who have a known allergy or hypersensitivity to the ingredients in semaglutide People who are already taking a GLP-1 weight loss medication Always talk to your provider about potential risks and health complications before starting a new medication