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In addition, TAX1BP1 can recruit autophagosomes through LC3-independent pathways [49]

GLP-1 analogs can be as effective as insulin in treating type 2 diabetes in people. Gilor and his colleagues at Ohio State have been studying the effects of these drugs in cats

These include activation of GLP-1 receptors on vagal afferent neurons in the gastrointestinal tract, which transmit signals to the brainstem, and potential action at circumventricular organsspecialized brain regions with a more permeable blood-brain barrier

10.1038/nature25015 Nature

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The brain is extremely sensitive to electrolyte imbalances