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However, in a more recent randomized, placebo-controlled study in 102 subjects, daily supplementation with 600 mg of lipoic acid (+/- 800 mg of vitamin E [-tocopherol]) for 16 weeks had no effect on fasting blood glucose, fasting blood insulin, or a measure of insulin resistance called the homeostatic model assessment of insulin resistance (HOMA-IR) index (59)

10.1111/j.2047-2927.2013.00096.x 73

RIP1Tag2 transgenic mice Expression of the SV40 large T antigen (Tag) under the control of the rat insulin promoter (RIP) causes -cell hyperplasia, which progresses through a series of rate-limiting stages to invasive pancreatic neuroendocrine tumour (PNET)

Am J Hematol 93:E91E93

W., Kema, I

KRAS signalling has been linked to enhanced mitochondrial metabolism by various mechanisms in colorectal, lung and pancreatic cancers 8,18 , as has APC and p53 (refs