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Further analysis of signaling pathways confirmed that PD effectively upregulated endogenous TGF-/Nodal signaling and downstream Smad2/3 transduction, while concurrently downregulating BMP signaling, leading to robust DE formation

K.et al (2005)

Melatonin attenuates myocardial ischemia-reperfusion injury via improving mitochondrial fusion/mitophagy and activating the AMPK-OPA1 signaling pathways

Combination with other cardiovascular interventions presents additional unknowns

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Understanding how peptides influence these processes explains why they help with scarring