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Lead study author, Hamlet Gasoyan, DS, PhD, MPH, a researcher with Cleveland Clinics Center for Value-Based Care Research, spoke to Medical News Today , emphasizing the importance of these results in a real-world setting: Randomized clinical trials documented that discontinuation of novel obesity medications generally leads patients to regain weight, Gasoyan told us

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To date, they represent the only G protein-coupled receptor (GPCR) ligands approved as glucose-lowering agents (2)

Rare or Severe Side Effects: What Requires Medical Attention While most side effects are mild and transient, you should contact your healthcare provider immediately if you experience severe abdominal pain, persistent vomiting, vision changes, rapid heartbeat, or signs of pancreatitis (upper left pain radiating to your back)

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Heart rate considerations Mazdutide consistently increases heart rate across all trial participants