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While urinary excretion of VC metabolites (oxalate, threonate) maintains systemic balance, prolonged deficiency ( ShacterEet alAscorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo

These can include personal or family history of medullary thyroid carcinoma, Multiple Endocrine Neoplasia syndrome type 2, history of pancreatitis, certain kidney or gallbladder conditions, pregnancy or breastfeeding, and other individual health factors

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Research shows sarcopenic obesity carries greater health risks than either obesity or low muscle mass alone

USA 105 , 1437114376 (2008)

MT COMPETING INTERESTS: Associate Professor Markovic is an investigator on pharmaceutical trials of semaglutide and CagriSema (NovoNordisk), tirzepatide and retatrutide (Lilly), BI 456906 (Boehringer Ingelheim) and maridebart/cafraglutide (Amgen)