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Indeed, several studies have demonstrated that aberrant IGF signaling plays a critical role in the pathogenesis and progression of several types of cancer, including lung, breast, colon, prostate, ovary, pancreas, and thyroid ( Nevertheless, data coming from observational studies are still conflicting and inconclusive, since some authors observe an association between insulin therapy and increased cancer risk (Tseng, 2019

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Proteins that bound preferentially to the tail fusion rather than GST alone were identified by mass spectrometry (Fig

The amount of visceral fat reduction significantly decreases the risk of cardiovascular events, type 2 diabetes, and several cancers

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