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Delays gastric emptying While taking semaglutide, food moves more slowly from your stomach into the small intestine

Indeed, germ-free mice exhibit reduced intestinal Glp1r expression and relative GLP-1 resistance (34) associated with elevated levels of circulating GLP-1 (36), consistent with an important role of the microbiota in determining GLP-1 sensitivity

Benefits Helps maintain lasting hydration

Lichtman SM, Andreeff M

If you're considering GLP-1 therapy and have chronic pain, understanding both the mechanisms and the evidence gaps is crucial for a productive conversation with your provider

Jensen CFS, stergren P, Dupree JM, et al