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Participant breakdown: Age distribution: 1829 (15%), 3044 (32%), 4560 (24%), 60+ (28%) Gender: 61% female, 39% male Geographic coverage: All major U.S

Transition strategies: Gradual dose reduction (tapering) versus abrupt discontinuation both acceptable

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Drosophila and mice with the Y314S variant both showed degeneration of dopaminergic neurons and locomotor defects (Lin et al., 2020), providing direct evidence for the involvement of cIII in PD pathogenesis

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Instead of building one molecule that hits more receptors, Novo Nordisk is combining two complementary peptide mechanisms