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Expression of EPAC1/2 is upregulated by PI3K-AKT signaling in melanocytes and EPAC2 activity is required for the growth of transformed melanocytes To test whether EPAC signaling is activated and plays a role during malignant transformation of melanocytes, we transformed cultured neonatal human melanocytes (NHM) with lentiviruses for oncogenic BRAF (BRAF V600E ) and/or short hairpin RNA (shRNA) for PTEN (phosphatase and tensin homolog)

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For those with medical conditions, it's crucial to consult a healthcare provider before starting the supplement