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Furthermore, it had an anti-inflammatory impact via stimulating cyclic adenosine monophosphate (cAMP)/ protein kinase A (PKA)/ cAMP response element (CRE)-binding protein (CREB) signaling pathway and shifting M1/M2 macrophage polarization towards the M2

Certain ASMs, particularly those that induce hepatic enzymes, can significantly alter the metabolism of VK, leading to deficiencies that may exacerbate seizure activity [154]

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11.1 events per 1,000 person-years

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