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Additionally, the promoter features an antioxidant response element (ARE) and metal response element (MRE) within the first 160 bp of the transcription start point, which respond to oxidative stimuli such as H 2 O 2 and tert-butylhydroquinone [35]

191,192,193 HSCs and endothelial cells HSCs are located within the unique ecological niche of the liver, which allows HSCs to communicate with hepatocytes and multiple other non-parenchymal cells through direct contact and paracrine interactions

Titration is the process of starting at a low dose and gradually adjusting it over time based on the bodys response

doi: 10.3390/biomedicines12081912, 70

Brain atrophy is the most direct biological readout of neurodegeneration available short of autopsy