This suggests that non-responders were less severely affected by ME/CFS at baseline, and that the main positive effect of nasal B12 administration occurs in more severely affected patients
This result was confirmed in a study on the mouse colon, where only GPX1 and GPX3 RNA decreased, while the RNA of GPX2 and GPX4 remained stable when mice were deficient in selenium (Kipp, 2017)
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If the DNA damage is too severe or there is a defect in the DNA repair pathway, DNA repair will ultimately fail 5-7
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