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219 Restoring autophagic flux enables the selective degradation of ER fragments containing misfolded proteins and lipids via autolysosomes, a process known as reticulophagy, which can markedly alleviate ER stress and help restore ER function
Alternative models: from humanized mice to microphysiological systems and beyond, in: Scientific and Regulatory Considerations for Assessment of Immunogenicity Risk for Generic Peptide and Oligonucleotide Drug Products at The Universities at Shady Grove, Rockville, MD (Day 2, Session 4),
In the 2025 study mentioned earlier, women receiving the combination therapy experienced an average weight loss of 6.09 kg (about 13.4 lbs) over 16 weeks, compared to 2.25 kg (approximately 5.0 lbs) in the metformin-only group
Science 374 , 12271237 (2021)