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47 Since p53 is stage-specific in the pathogenesis of liver injury, p53 may not be an ideal target for treating AIH

10.1038/s41568-022-00459-0 81 LeiJ.LuoD.XiongJ.LiM

Power of proteomics in linking oxidative stress and female infertility

Subsequent work by Sun and colleagues in the APP/PS1 mouse model identified downstream PI3K/AKT pathway activation as a major component of the mechanism, with the PI3K inhibitor wortmannin reversing Dihexas anti-inflammatory and anti-apoptotic effects [5]