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Being on any combination therapy early in the disease is associated with enduring advantages, sometimes termed "legacy effects," in which benefits lag behind for a while [39], [41]

Stress Reduction Potential Research into DSIP often examines its capacity to aid in stress reduction through cortisol regulation

Long-term impact on total cost of care also remains to be seen. Employer groups are wondering if employees who are taking the drug for diabetes will be on them indefinitely, creating a costly, new, long-term budget concern with lingering questions about any savings from reductions in obesity-related illness

But it would be a small miracle if all of their additional effects, whether separate from or downstream of weight loss, are what help obesity drugs become as widely available as so many other life-changing treatments.

The sample size was determined by reference to a previous report [17]