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The uricosuric agents targeting the URAT1 transporter, such as lesinurad and dotinurad, along with the formulation of oral combination therapies comprising xanthine oxidase inhibitors and uricosuric agents, is poised to improve the attainment of the target serum uric acid level of less than 6 mg/dL

This idea was bolstered by a series of experiments conducted between 1890 and 1905 by Marcel Eugne mile Gley, a French physiologist

For many patients, constipation improves within the first few weeks as the dose stabilizes and the body adapts