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Supplementary material The Supplementary Material for this article can be found online at: Abbreviations KDT, Ketogenic dietary therapy
Reported Effects Mild and infrequent effects reported in research include transient nasal irritation (intranasal administration), mild headache, and short-lived changes in alertness
This results in a tingling or burning sensation in the affected areas, as well as a lack of sensation and the inability to feel changes in temperature
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In theory, this may result in: Darker skin pigmentation Faster tanning when exposed to UV light However, the compound does not act selectively on the skin
Likely explanations include GHSR-1a polymorphisms reducing receptor sensitivity, chronically elevated somatostatin tone (seen in high-stress, poor-sleep populations), and already-high baseline IGF-1 that limits room for further elevation via negative feedback
