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As a result, patients treated with valproic acid presenting with signs and symptoms of acute mental status changes, increased seizure frequency, and/or gastrointestinal symptoms should be evaluated for elevated ammonia concentrations

Can be layered with body serum for enhanced hydration

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Because DSIP may interact with neurotransmitter systems such as GABA and NMDA pathways, combining it with sedatives, alcohol, or other neuroactive substances could amplify drowsiness or increase the risk of neurological side effects

The enzyme that produces NAPQI, CYP2E1, is an inducible enzyme and thus, with other substances such as ethanol, can be induced and possibly create more NAPQI and liver injury on its own