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Focusing on dynamic associations between metabolism and disease stages, longitudinal metabolomic cohort studies can track changes in metabolic profiles of patients from early asymptomatic stages to stable and acute exacerbation phasesidentifying core metabolic characteristics at different disease stages and addressing gaps in the current understanding of correlations between disease staging and metabolic abnormalities

10.1038/ncomms7018 230

ISBN 978-0-253-31222-8

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