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15 The incidence of IR in Asian-Indians is approximately 2 to 3 times greater than that in other races, 16 possibly related to their phenotypes of high fat mass and low lean mass, indicating higher insulin levels

This extended action increases the risk of side effects seen with prolonged GH elevation: facial flushing, water retention, joint stiffness, and numbness or tingling in hands (carpal tunnel symptoms)

This shifts pigment balance away from eumelanin (darker pigment) and toward pheomelanin (lighter pigment), gradually leading to a brighter, more even complexion

In this context, portfolio strategies become more visible during this era, as leading players seek to position multiple assets across induction, maintenance, label expansion and distinct patient segments in an increasingly crowded market

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