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Unlike regular IGF-1, IGF-1 LR3 has an extended half-life, which prevents rapid degradation and allows it to remain active in the body longer (4)

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Treatment with L-carnitine resulted in the correction of L-carnitine deficiency in all our patients

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Thus, by activating the coagulationinflammation axis, worsening the local microenvironment, promoting urate crystal aggregation, and accelerating tissue fibrosis, hypercoagulability contributes significantly to tophus development and persistence