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They showed that semaglutide enhanced histological parameters of fibrosis and inflammation while decreasing hepatic expression of genes associated with fibrotic and inflammatory cascade: through proteomic profiling of serum from MASH patients treated with semaglutide, they detected 72 proteins linked to disease resolution and validated these findings in preclinical mouse models and an independent patient cohort [28]
Hashimotos thyroiditis and hypothyroidism are not contraindications to GLP-1 therapy
Pathophysiology of NAFLD and NASH in experimental models: The role of food intake regulating peptides
Protect it by: Getting daily protein from a variety of plant and dairy sources Adding 2 to 4 days a week of strength work (body-weight, resistance bands, or weights) Avoiding very low-calorie crash dieting on top of GLP-1s Injection technique and monitoring For injectable GLP-1s: Rotate injection sites (abdomen, thighs) to reduce lumps and irritation
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