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Targeting more than one receptor seems to boost the medications weight-loss effects

It is not known if this applies to humans

Protective effects of GLP-1 analogues exendin-4 and GLP-1936 amide against ischemiareperfusion injury in rat heart

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These compounds share similar pharmacokinetics and safety profiles, while effectively improving glycemic control and potentially offering additional benefits for cardiovascular health

Meta-analyses have further confirmed that dual GLP-1/GIP receptor agonists are more effective than single GLP-1RAs in reversing liver fibrosis and reducing hepatic fat accumulation, suggesting a dose-dependent and receptor-combinatorial effect on liver outcomes (48)