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Already used as a drug to treat hypoglycaemia, DiMarchi began working on finding a better way to synthesise glucagon so that it could be administered more easily

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And obesity medicine specialists and researchers have known this for a long time

Subgroup analysis indicated that homozygous mutations were associated with more severe impairment of long-term weight loss than heterozygous mutations, which explains why bi-allelic MC4R mutation carriers have poorer long-term outcomes than heterozygous carriers

After being granted a fast-track designation for weight loss by the FDA (October 22), tirzepatide is expected to be approved for obesity later this year

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