Ultra-sensitive quantification of the therapeutic cyclic peptide bremelanotide utilizing UHPLC-MS/MS for evaluation of its oral plasma pharmacokinetics
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TBT at relatively high concentrations as hundreds of nanomoles has been found in human blood (Antizar-Ladislao, 2008) and the lipophilicity of organotin compounds favors their toxicity at membrane level, as well as disrupting diverse biological processes, involved in the endocrine, (Sharan et al., 2013) the immune, (Brown & Whalen, 2015) and nervous systems (Dong et al., 2006)
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