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BMP-2, released into the bone matrix during osteoclast-driven bone resorption, is the primary agent differentiating BMSCs into osteoblasts

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Moreover, the more rapid reduction in weight due to caloric restriction on GLP-1 (semaglutide) or GLP-1/GIP (tirzepatide) can accelerate hormonal imbalance and heighten the risk of muscle wasting and the onset of osteoporosis

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