Role of lipotoxicity and contribution of the renin-angiotensin system in the development of polycystic ovary syndrome
Neurosci 7, 22942300
(This explains why hydroquinone has long been used for melasma removal , where brown or gray-brown patches of skin appear on foreheads, cheeks, chins and bridge of the nose.) In smaller doses (of at most 2%), hydroquinone can be purchased over-the-counter but pigment removal products with at least 4% hydroquinone concentration (considered to be the most effective concentration), require a prescription from a skin care specialist
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