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Enbrel and Remicade), p38 inhibitors, adenosine Al receptor agonists (e.g., R-PIA), somatostatin analogs, semapimod (CNI1493), caspase inhibitors, STAT inhibitors, JAK inhibitors, Trp channel inhibitors (e.g., BCTC), MET channel and other ion channel inhibitors, OCT2 transporter inhibitors (e.g., trospium chloride), CTR1 transporter inhibitors, and inhibitors of cyclin-dependent kinases, including CDK2 inhibitors

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While human dataparticularly in BD populationsremain limited, evidence points to potential adjunctive benefits, especially in individuals with metabolic or cognitive vulnerabilities

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Submitting appropriate premarket submissions to the FDA (Stages 4 and 5) vary depending on how much information needs to be documented and what information is already available