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Figure 2 4.3.2 Amplification of immune responses by released intracellular components following ferroptosis When ferroptosis leads to the rupture of chondrocytes or synovial cells, the oxidized lipid byproducts, iron ions, and damage-associated molecular patterns (DAMPs) that leak from these cells are detected by nearby immune cells

Group B (n=85) received 250 mg of the same conventional agent with placebo

213 It also downregulates inflammatory cytokines, including TNF- and IL-6, through the SIRT1NF-B axis, mitigating chronic inflammation

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Men are affected by age, too