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Moreover, supplementation with Se could enhance the expression of GPX4 in follicular helper T cells and increase the number of helper T cells to improve the antibody responsiveness of immunized mice after vaccination [30], indicating that the regulation of Se on GPX4 plays an essential role in normal mammalian embryos

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The findings for this outcome need to be interpreted cautiously as there is no evidence to support whether this historical cohort is representative of contemporary children with untreated SPIGFD