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In the Pyo 2007 study (PMID 17703734), AHK-Cu increased dermal papilla cell proliferation, raised VEGF, lowered TGF-beta1, and shifted apoptosis markers toward survival a pattern the authors interpreted as prolonging the anagen (growth) phase

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KPV exerts its anti-inflammatory effects through intracellular pathways, independent of melanocortin receptors (MC-Rs)

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