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Liver fibrosis is a key determinant of disease progression, and higher fibrosis stages are associated with an increased risk of liver related complications, including cirrhosis, HCC, and liver failure [45]

Engages cellular senescence pathways: Cellular senescence is characterized by growth arrest and altered gene expression

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However, these models fail to accurately replicate physiological conditions due to their simplified (2D) microenvironment, phenotypic and genetic instability and functional alterations in culture [48]

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