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These findings were confirmed in humans by assessment of lactate concentrations in jejunal biopsies incubated with and without metformin [13]

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For the analyses of this estimand, missing values (unobserved due to patient loss to follow-up or other reasons) were assumed to be missing at random and were handled by multiple imputation using observed data in the placebo group

These agents provide multiple benefits, including weight reduction, cardio-renal protection, improved heart failure symptoms and hepatic steatohepatitis, and overall reduced mortality [2,3,4,5,6,7,8,9]

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