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It is an investigational drug still in Phase 3 trials and is legally available only to people taking part in Eli Lilly's clinical studies

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Importantly, early-phase trials of short-term NAD+ precursor administration have proven safe and increase NAD+ levels in healthy participants

Cost Comparison: Real 2026 Numbers A patient paying cash for Zepbound will pay roughly $15,000 per year at pharmacy retail, or about $5,400 per year at LillyDirects $449 self-pay maintenance rate

Warning Signs Most semaglutide side effects are gastrointestinal in nature