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People taking semaglutide for weight loss may experience: Dizziness Fatigue Gastrointestinal issues, such as diarrhea, constipation and gassiness Headache Stomach issues, including nausea, vomiting, pain or distension (bloat) Gastrointestinal issues are the most common complaint among people just starting semaglutide
Always seek the advice of a qualified healthcare provider, such as Dr
Pregnancy, certain digestive disorders, medication interactions, and other medical factors may affect treatment selection
When pharmacotherapy is needed, alternatives include phentermine-topiramate (Qsymia), which requires monitoring for psychiatric effects and is contraindicated in pregnancy
Phase 2 trial data (NEJM, 2023) showed a mean body weight reduction of approximately 24% at the highest dose (12 mg weekly) over 48 weeks in adults without type 2 diabetes
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