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Absolute contraindications Medullary thyroid cancer MEN-2 Pregnancy or breastfeeding Prior severe allergic reaction to GLP-1 medications Conditions requiring extra caution Gastroparesis or delayed gastric emptying History of pancreatitis Advanced diabetic retinopathy Use alongside medications that increase hypoglycemia risk These and a few other situations require individualized assessment, which is why specialty endocrine care matters

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The appetite-suppressing effects occur through complex interactions with the central nervous system, which has led researchers to hypothesise that these medications might influence other reward-driven behaviours, including alcohol consumption

Retatrutide should be taken on the same chosen day each week to maintain consistent drug levels