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Its defining hallmark is the profound crosstalk and functional integration among distinct resistance mechanisms

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However, this was not associated with a significant improvement in motor behavior[42], suggesting that targeting muscle alone without restoring motor neuron function is not sufficient to reverse a severe form of SMA

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GLP-1 agonists (Table 1) activate GLP-1 receptors located in multiple organs, including the pancreas, gastrointestinal tract, and brain, which potentiate glucose-stimulated insulin secretion and assist in diabetic control [4,5,6]

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